Objective: This retrospective study was designed to evaluate the efficacy and safety of doxycycline in patients with a history of urinary tract infection (UTI) who received a prolonged period of therapy with doxycycline.
Objective: The study included 724 adult patients with a history of UTI who had received an antibiotic regimen with doxycycline for at least one year. The patients were randomly assigned to receive a 1:1, 3 mg daily doxycycline regimen followed by a 7-day course of oral doxycycline (400 mg). The primary outcome was the overall incidence of adverse events (AEs) during the study period.
Method: The study was conducted in the Department of Obstetrics and Gynecology of the University of Graz in Austria. The patients were included in the study if they had a UTI that lasted longer than 5 days or had no signs of infection, had an active history of UTI, were free of any other chronic disease or chronic illness, and had no history of other chronic illnesses such as diabetes mellitus, high cholesterol, hypertension, hypertension or smoking. The patients were followed for a mean period of 28.8 ± 17.4 months after the start of the study.
Patients were randomly assigned to receive the doxycycline regimen with oral doxycycline 400 mg for 7 days or with oral doxycycline 12.5 mg for 6 days (n = 6).
Main outcome measures were the incidence of AEs during the study period, and the percentage of the patients who discontinued treatment. The data were analyzed by using statistical package JASP v9.
Results: The mean age of the study patients was 39.9 ± 6.5 years. Overall, there were more AEs (14.8%) during the study period and an AEs (6.5%) during the 6-day course of treatment than during the 7-day course (2.3%). Among the patients who were free of other chronic diseases, the overall incidence of AEs was higher during the study period (18.8%) than during the 7-day course (3.7%). Among the patients who were free of other chronic illnesses, the overall incidence of AEs was higher during the study period (27.5%) than during the 7-day course (3.9%). The AEs most commonly recorded during the study period were those for diarrhea (2.3%), and nausea (2.8%), with a higher incidence in the doxycycline group compared with the patients on the 7-day course (2.7%) (P <.001).
Conclusion: The results indicate that doxycycline is effective for a period of 7 days in the treatment of patients with UTI who received a prolonged period of antibiotic treatment.
Citation:Filippini V, Benvenuti V, Piazza P, Betti G, Vazquez-Cerbaum C (2016) Efficacy and safety of doxycycline in a prospective, open-label, randomized, double-blinded study of patients with a history of UTI.Front Reprod. Respir Rep. (2017) DOI:doi:
Copyright© 2016 GABAC, Anadolica, Inc. This document is intended for educational purposes and is not intended for medical advice.
Received:June 16, 2017;Accepted:May 28, 2016;Published:May 30, 2016
Funding:No funding for this study was provided by the University of Graz. This study was not designed to support any study of this nature.
The authors declare no conflict of interests.
Benvenuti V, Benvenuti V, Piazza P, Betti G, Vazquez-Cerbaum C, Vazquez-Cerbaum C (2016) Efficacy and safety of doxycycline in a prospective, open-label, randomized, double-blinded study of patients with a history of UTI.N Engl J Med. 2017;350(11):2592-2596.
To prevent malaria, doxycycline is recommended as malaria prophylaxis. It is effective against bothPlasmodium falciparumandP. knowlesiinfections.
Doxycycline is an oral antibiotic (the drug class name) used to treat malaria and to prevent the complications of malaria. It is not a cure for malaria. It is used to prevent malaria.
Doxycycline works by inhibiting the growth of parasites. This means it prevents the multiplication of the parasites, which helps to prevent malaria. It does not treat malaria; it only kills the parasites.
Doxycycline has been approved by the Food and Drug Administration (FDA) for the treatment of malaria.
Doxycycline is taken orally with or without food. It is usually taken once daily at the same time(s).
Doxycycline is not suitable for pregnant women, children under the age of 12, women who are pregnant or breastfeeding, and people who have liver, kidney, or lung disease.
Do not take doxycycline if you have ever had an allergic reaction to it, or any of the ingredients listed in the patient information leaflet.
Doxycycline is used to prevent malaria in children under the age of 12. It is also used to prevent malaria in adults who are at risk of infection with, the most commonPlasmodium vivaxinfection.
Doxycycline is usually given when other treatment options are not enough to control the infection. It is available in the form of tablets.
Doxycycline is sometimes used to prevent malaria after a long illness, such as in the case of pneumonia.
Doxycycline is usually taken once a day for 3 days, with or without food. It can be taken with or without food.
Before taking doxycycline, tell your health care professional about all of your health conditions, including if you:
You should not use doxycycline if you are allergic to any of the ingredients listed in the patient information leaflet.
You should not use doxycycline if you are taking a monoamine oxidase inhibitor (MAOI), such as phenelzine, tranylcypromine, moclobemide, and lead (Parnate) in the treatment of depression.
Doxycycline should be taken with or without food. Follow the directions on the prescription label or the packaging. Swallow the tablet with a full glass of water. Do not crush or chew the tablet, as it can cause irritation to the esophagus.
Store doxycycline at room temperature in a tightly closed container. Keep it out of the reach of children.
Do not use if you are allergic to any of the ingredients listed in the patient information leaflet. Do not use the tablet with or without food.
Do not take doxycycline if you are pregnant or breastfeeding. It is not known if doxycycline passes into your breast milk. Do not take doxycycline if you are allergic to any of the ingredients listed in the patient information leaflet.
Side Effects:Doxycycline side effects in dogs, cats and horses include stomach upset, vomiting, reduced appetite, and diarrhea. Giving doxycycline with food may help alleviate these GI effects. Reddening or sunburn can occur to hairless skin around nose, eyelids and ears when exposed to sunlight.Warnings:Do not use in animals allergic to doxycycline or other tetracycline drugs. Use with caution in animals with liver problems. Milk or other dairy products, calcium, oral antacids, iron, or bismuth subsalicylate must be separated from doxycycline doses by at least 2 hours. Overdoses can be very dangerous. Keep out of reach of children and animals. Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian. If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give two doses at once. This medication should only be given to the pet for whom it was prescribed.
Side Effectsdogs, cats and horses 1 tablet a day 0.5 g or 2.0 g daily for 5 years. Use in conjunction with a reduced-calorie diet 3. or 4.oz. product with mineral content 40-50mg/lb,gamma-carotene-microcrystallineization,lethyn-o-a-l x 30-40 mg/g bismuth subsalicylate, and a dyester of aluminum lake (E132) and calcium lake (E172). If weight loss is not possible, continue with diet. Also, if your pet has vomiting, stomach cramps, or diarrhea, contact your veterinarian.
TerAPEal can be used in combination with a reduced-calorie diet 3. product with mineral content 40-50mg/lb,gamma-carotene-microcrystallization,lethyn-o-a-l x 30-40 mg/g bismuth subsalicylate, and a dyester of aluminum lake (E132) and calcium lake (E172). Tetracyclines, such as doxycycline, can sometimes pose serious side effects. Contact your veterinarian at the dose of 2.g. or 4.g.a. week after giving a tetracycline.
Discontinue this medication when you begin your new cycle and give it to the next person. Do not give it to anyone less than the pet’s weight.
Most Side Effects are Less Withdrawn From Coronavirus:
Sign up for our full range of Keflex™ and experience the most on your Keflex™® product. The free download below will be taken from our website.
Do not give to less than 1 pet, but give to 1 pet if you have complete information about this medication, whether it is safe for you to take, and if it works.
SKU:No product marketed for dogs & cats on this label.
Keflex™ is a nonprescription medication that may be prescribed for your pet if they are qualified to take it.
All medications contain the same active ingredient, doxycycline, and all ingredients are equally available in their markets.nonprescription brands include, but are not limited to, amoxicillin, and clavulanic acid. Other names for amoxicillin are of course the same as the active ingredient in this medication.Doxycycline is an antibiotic used to treat a wide range of bacterial infections, including acne, rosacea, Lyme disease, and malaria. Doxycycline is effective in treating many of these infections but has a few common side effects.
Doxycycline side effects may include:
In rare cases, Doxycycline can cause a serious skin reaction called Stevens-Johnson Syndrome or Reye’s enterocolitis.
Doxycycline may cause other side effects, including:
If you experience any of these symptoms, call your doctor at once and stop using Doxycycline. Do not take more or less of it than prescribed.
In rare cases, Doxycycline may cause a serious skin reaction called Stevens-Johnson Syndrome or Reye’s enterocolitis.
It’s important to know that Doxycycline is not effective in treating all types of bacterial infections. However, it can still cause side effects in some individuals. This includes:
If you notice any unusual symptoms while taking Doxycycline, stop using this drug and contact your doctor immediately.
If you have any questions or concerns about taking Doxycycline, ask your doctor or pharmacist.
Doxycycline may cause some side effects. This is a general list of side effects that may occur. For more information, you can call the Poison Control Center at 1-800-222-1222.Doxycycline may cause:Some side effects may be more likely to occur if you take Doxycycline at least twice a day for a day to day basis.
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